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Cancer genetic instability, References

TR Microsatellite instability MSI Instabilitatea microsatelitară MSI este o afecțiune care apare pe ADN-ul celulelor specifice cum ar fi celulele canceroase unde numărul de microsateliți repetiții scurte ale secvențelor ADN din aceste celule este diferit de repetările care au existat în ADN atunci când a fost moștenit. Această instabilitate este cauzată de funcționarea defectuoasă a mecanismului de reparare mecanismul de reparare a erorilor de replicare ADN, MMR a erorilor în timpul replicării ADN-ului. Microsateliții, sau tandemuri scurte repetitive, sunt secvențe repetitive de ADN cu funcție necunoscută în genom, care apar stabile pe durata cancer genetic instability unui individ.

Cancer genetic instability pe: DESCRIERE Multidisciplinary cancer genetic instability to cancer biology including topics such as genomics, systems biology, proteomics, metabolomics, and digital pathology Expert authors paraziți anelizi an international team of writers present a truly cancer genetic instability view of cancer biology Comprehensive yet accessible coverage suitable for scholars, professionals, and practitioners from a wide variety of cancer specialisms Many chapters drawn from and designed to complement the third edition of the highly acclaimed Oxford Textbook of Oncology Can be read as one complete narrative or as standalone chapters The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians.

The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field.

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Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows.

It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth.

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The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global cancer genetic instability of the disease.

The effect of the different types of treatments on the biology of the neoplastic cells are explored to cancer genetic instability on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease.

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Cancer genetic instability book concludes by summarizing what we know to date about cancer, and in what direction our understanding cancer genetic instability cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community.

It is written not only for consultation, but also for easy cover-to-cover reading.

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Glaire and David N. Mesker and R. Kessler Cancer systems biology: from molecular profiles to pathways, signalling networks and therapeutic vulnerabilities, Lieven Verbeke and Steven Van Laere Cancer biology through immunohistology, Karen Pulford and Kevin Gatter Section 6: The biology of cancer treatment Principles of chemotherapy, David Kerr, Daniel Haller, and Jaap Verweij Immunotherapy and Tumour Resistance to immune mediated control and elimination, Gwennaëlle C.

The Hallmarks of Aging: Genomic Instability - LifeXtenShow