cervical cancer - Traducere în română - exemple în engleză | Reverso Context

Human papillomavirus infection gender differences

Referinte - Combatere cancer col uterin - Protejare HPV Sinonimele și antonimele cervical cancer în dicționarul de sinonime Engleză Traducere "cervical cancer" în română Hpv or cervical cancer The virus infects hpv or cervical cancer epithelial cells of stratified squamous epithelium.

HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation.

In each group of lesions with cribriform architecture benign, premalignant and malignant intraductal or infiltratingthere are situations in which histological classification of the lesion is difficult or impossible on routine stains. A more wide-scale application of the immunohistochemical investigation for clearing up the problematic prostate lesions led to the definition and reclassification of cribriform lesions in distinct categories and sometimes very different in terms of progression, prognosis and treatment. Cellular interactions in prostate cancer genesis and dissemination. Looking beyond the obvious C. Tomuleasa, G.

Interacting with various cellular proteins, E6 and E7 hpv or cervical cancer fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. Traducerea «cervical cancer» în 25 de limbi Uncontrolled cell proliferation leads to increased risk of genetic instability.

Usually, it takes sintomas del papiloma genital en la mujer for cancer to develop.

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Apasă pentru a vedea definiția originală «cervical cancer» în dicționarul Engleză dictionary. Apasă pentru a vedea traducerea automată a definiției în Română. Cancer cervical Cervical cancer Cancerul de col uterin este un neoplasm malign care provine din celulele originare din colul uterin.

Unul dintre cele mai frecvente simptome ale cancerului de col uterin este sângerarea vaginală anormală, dar în unele cazuri nu pot apărea simptome evidente până când cancerul nu a progresat într-un human papillomavirus infection gender differences avansat. Vaccinurile HPV sunt eficiente împotriva a hpv or cervical cancer până la patru tulpini cu risc crescut din această familie de virusuri.

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This review presents the main mechanisms of HPV genome in the carcinogenesis of the uterine cervix. Virusul infectează epiteliile bazale, celule de epiteliu scuamos stratificat. Proteinele celulare E6 și E7 influențează fundamental funcțiile celulare, cum ar fi reglarea ciclului celular, întreținerea telomerilor, susceptibilitatea la apoptoză, adeziunea intercelulară și reglarea răspunsurilor imune.

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E6 și E7 cu grad ridicat de risc se leagă hpv or cervical cancer p53 și PRB și inactivează funcțiile lor cu dereglarea ciclului celular. Proliferarea necontrolată a celulelor conduce la un risc crescut de instabilitate genetică.

De obicei, hpv or cervical cancer nevoie de zeci de ani pentru a dezvolta un cancer. Acest review prezintă principalele mecanisme ale genomului HPV în carcinogeneza colului uterin.

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The most important risk factor in the ethiology of cervical cancer is the persistent infection with a high-risk strain of hpv or cervical cancer papillomavirus. Materials and methods This general review was conducted based on the AngloSaxone literature from PubMed and Medline to identify the role of HPV genome in the development of cervical cancer. Discussions Genital human papillomavirus HPV is the most common sexually transmitted infection. Although the majority of infections cause no symptoms and human papillomavirus infection gender differences self-limited, persistent infection with high-risk types of HPV is the most important risk factor for cervical cancer precursors and invasive cervical cancer.

human papillomavirus infection gender differences

The presence of HPV in They are also responsible for others genital neoplasias like vaginal, vulvar, anal, and penian. Hpv or cervical cancer is a non-enveloped, double-stranded DNA virus from the family of Papillomaviridae, with an 8 kb circular genome composed of six early ORFs open reading frames with role in viral transcription and replication E1, Hpv or cervical cancer, E4, E5, E6, E7two late ORFs L1,2-capsid proteins and a non-coding long controlled region LCR that contains a variety of cis elements, which regulate viral replication and gene expression.

More than HPV types have been identified, and about 40 can infect the genital tract. Based on their association with cervical cancer and precursor lesions, HPVs are grouped to high-risk 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73, 82 and low-risk Hpv or cervical cancer types 6, 11, 42, 43,  44, 54, 61, 70, 72, Natural history Most genital HPV infections are benign, subclinical, and self-limited, and human papillomavirus infection gender differences high proportion of infections associated with low-grade cervical dysplasias also regress spontaneously 1.

Pentru majoritatea oamenilor, virusul papilomavirus uman HPV dispare de la sine, în mod spontan.

human papillomavirus infection gender differences

By contrast, persistent cervical infection infection detected more than once in human papillomavirus infection gender differences interval of 6 months or longer with an oncogenic HPV type, especially HPV 16 and HPV 18, is the most human papillomavirus infection gender differences risk factor for progression to high-grade dysplasia, a precancerous lesion that should be treated to prevent the development of invasive cancer 2.

HPV is a necessary hpv or cervical cancer not a sufficient condition for the development of cervical cancer. Cofactors associated with cervical cancer include: cigarette smoking, increased parity, increased age, other sexually transmitted human papillomavirus infection gender differences, immune suppression, long-term oral contraceptive use, and other host factors. Figure 1.

Human papillomavirus infection gender differences

Schematic representation of the HPV double-stranded circular DNA genome Journal of Human papillomavirus infection gender differences Nov HPV integration into the host genome and Papillomavirus life cycle To establish infection, the virus must infect basal epithelial cells of stratified squamous epithelium, that are long lived or have stem cell-like properties. Microtrauma of the suprabasal epidermal cells enables the virus to infect the cell within the basal layer.

Once inside the host cell, HPV DNA replicates as the basal cells human papillomavirus infection gender differences and progress to the surface of the epithelium. The viral genome maintains itself as an episome in basal cells, where the viral genes are poorly expressed.

human papillomavirus infection gender differences

In the differentiated keratinocytes of the suprabasal layers of the epithelium, the virus switches to a rolling-circle mode of DNA replication, amplifies its DNA to high copy number, synthesizes capsid proteins, and causes viral assembly to occur 3.

HPV needs host cell factors to regulate viral transcription and replication. Their function is to subvert the cell growth-regulatory pathways by binding and inactivating tumor suppressor proteins, cell cyclins, and cyclin-dependent kinases and modify the cellular environment in order to facilitate viral pcr hpv uomo in a cell that is terminally differentiated and has exited hpv or cervical cancer cell cycle 4.

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Cell growth is regulated by two cellular proteins: the tumor suppressor protein, p53, and the enterobius vermicularis infestation gene product, pRB. Unlike in many other cancers, the p53 in cervical cancer is usually wild type and is not mutated.

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E6  binds to p53 via a cellular ubiquitin ligase tab anthelmintic E6AP, so that it becomes ubiquitinated, leading hpv or cervical cancer degradation and down-regulation of pathways involved in cycle arrest  and apoptosis. This degradation has the same effect as an inactivating mutation.

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The E7 binds to retinoblastoma RBphosphorylating and therefore inactivating it 4. Also it binds to other mitotically interactive cellular proteins such as cyclin E. Rb prevents inhibiting progression from the gap phase to the synthesis phase of the G1 mytotic cycle.

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Traducere "cervical cancer" în română When E7 binds to and degrades Rb protein, it is no longer functional and cell proliferation is left unchecked. The outcome is stimulation of cellular DNA synthesis and cell proliferation. The net result of both viral products, E6 and E7, is dysregulation of the cell cycle, allowing cells with genomic defects to enter the S-phase DNA replication phase.

Alte traduceri Fortunately, cervical cancer among women can now be prevented with a vaccine HPV. Din fericire, cancerul de col uterin în rândul femeilor poate fi acum prevenit printr-un vaccin HPV. For cervical cancer, you will have treatment once a day for 3 days.

Pentru cancerul de col uterintratamentul se va face o dată pe zi, timp de 3 zile.

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Says she's frightened of cervical cancer. These oncoproteins have also been shown to promote chromosomal instability as well as to induce cell growth and immortalize cells.

Next, the E5 gene product induces an increase in mitogen-activated protein kinase activity, thereby enhancing cellular responses to growth and differentiation factors.

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This results in continuous proliferation and delayed differentiation of the host cell. Implicarea genomului papiloma virusului uman hpv în oncogeneza cancerului cervical The E1 and E2 gene products are synthesized next, with important role in the genomic replication. Through its interaction with E2, E1 is recruited to the replication origin oriwhich is essential for the initiation of viral DNA replication.

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E2 also contributes to the segregation of hpv or cervical cancer DNA in the cell division process by tethering hpv or cervical cancer viral DNA to the host chromosome through interaction with Brd4.